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Boster Bio
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Boster Bio
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Cedarlane
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Mabtech Inc
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FineTest Biotech Inc
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Jingmei Biotech Co Ltd
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Merck & Co
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Diagnostica Stago
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PREDICTA S A
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Image Search Results
Journal: Pharmaceutics
Article Title: Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens
doi: 10.3390/pharmaceutics14010113
Figure Lengend Snippet: ELVN-34 reduce the expression of pro-inflammatory cytokines, chemokines and cell adhesion molecule in HNEpC challenged with LPS or poly(I:C). HNEpC challenged with LPS or poly(I:C) (30 μg/mL) display enhanced production of pro-inflammatory cytokines and chemokines IL-6, IL-1β, IL-8/CXCL8, CCL2/MCP-1, CXCL1/KC/GRO, VEGF, and cell adhesion molecule ICAM1(CD54) compared to non-treated cells. This increase in the production of pro-inflammatory molecules is abrogated by the addition of ELVN-34 (500 nM) 30 min post-challenge. LPS and poly(I:C) induce a reduction of anti-inflammatory IL-10 expression in HNEpC that is restored to normal levels after treatment with ELVN-34 (500 nM). The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
Article Snippet: In addition, the expression of the following cytokines was analyzed in the supernatant of HNEpC exposed to different allergic inductors: IL-6 (Catalog# 6802, Chondrex) range of detection: (9–600 pg/mL),
Techniques: Expressing
Journal: Pharmaceutics
Article Title: Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens
doi: 10.3390/pharmaceutics14010113
Figure Lengend Snippet: HDM triggered multiple signaling in HNEpC. HNEpC challenged with HDM ( D. farinae + D. pteronyssinus ) (30 μg/mL) induces the expression of several genes related with autophagy (ATG3, ATG5, ATG7, BECLIN-1, and P62), unfolded protein response (UPR) (ATF6, CHOP, and IRE1), and matrix metalloproteinases (MMPs) (MMP8, MMP2, MMP9, MMP3, MMP12, TIMP1, and TIMP2). HDM stressors also induce the expression of senescence (P21, P16, P27, and P53) and inflammation genes (IL-1α, IL-6, and IL-1β) on HNEpC. The treatment with ELVN-34 Na (500 nM) reduces the expression of autophagy, UPR, MMP, senescence (except P53), and inflammation genes induced by HDM extracts. The results showed the averages of three independent experiments. (**** p < 0.0001, NS—not significant).
Article Snippet: In addition, the expression of the following cytokines was analyzed in the supernatant of HNEpC exposed to different allergic inductors: IL-6 (Catalog# 6802, Chondrex) range of detection: (9–600 pg/mL),
Techniques: Expressing